Institute for Cancer Research has since its foundation in 1954 played a central role within the field of cancer research both in Norway and internationally. The Institute has seven research departments and more than 380 employees. About 70% of the employees and projects are externally funded. Read more
See introductory video with welcome to the ICR
Mitochondria are essential for cellular energy production and homeostasis, and their selective degradation through mitophagy is critical for maintaining cell function. However, the molecular mechanisms governing this process remain incompletely understood.
Now, Laura Trachsel-Moncho and co-workers in Anne Simonsen’s group identify the endosomal protein SNX10 as a modulator of piecemeal mitophagy, a process involving the selective degradation of mitochondrial components. They show that SNX10 localizes to early endosomes in normal conditions but associates with mitochondria-containing endosomal structures under hypoxia-mimicking stress. Loss of SNX10 leads to increased turnover of specific mitochondrial proteins, reduced mitochondrial respiration, and elevated reactive oxygen species (ROS) levels. Furthermore, zebrafish larvae lacking Snx10 exhibit reduced COX-IV levels and increased oxidative stress and cell death, demonstrating the physiological relevance of Snx10 in mitochondrial homeostasis.
These findings uncover an unexpected role for SNX10 in mitochondrial quality control and highlight its importance in cellular adaptation to metabolic stress.
Invitation from the UiO Growth House:
Welcome to this meeting place where we want to inspire researchers and students, give them self-confidence and knowledge about the innovation process, help them build networks, and facilitate collaboration between academia and industry. This hangout is a collaboration with Oslo Cancer Cluster and Oslo Cancer Cluster Incubator.
Time and place: Apr. 3, 2025 5:00 PM – 8:00 PM, Oslo Science Park
Programme and registration form (uio.no)
Oslo University Hospital hereby announce research awards in the following two catagories for 2025:
Closing date for nominations: March 7th 2025.
Mev Dominquez-Valentin from the Department of Tumor Biology at the Institute for Cancer Research is senior author on a study recently published in the prestigious journal Clinical Gastroenterology and Hepatology, entitled: "Characterization of Screening Strategies for Lynch Syndrome in Latin America.” The study involves the collaborations of more than 50 investigators from 24 representative genetic cancer registries/center of 8 countries from Latin America, highlighting the significant insights we've gained into Lynch Syndrome (LS) screening methods across the region. The results emphasize challenges in hereditary cancer syndrome screening in Latin America and the need for enhanced strategies. Other OUS researchers involved in the study are Eivind Hovig, Pål Møller and Vessela Kristensen.
Do you have an innovative idea based on your research for a new product or service, but need funding to develop your early-stage technology or service further?
Apply for seed funding from The UiO Growth House!
Application deadline: 20 March 2025.
